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低線量放射線反復被ばくの発がんへの関与
https://uoeh-u.repo.nii.ac.jp/records/744
https://uoeh-u.repo.nii.ac.jp/records/744fe8691e4-cba9-4df3-ae34-de2168ce4c96
名前 / ファイル | ライセンス | アクション |
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S00038207 (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-08-03 | |||||
タイトル | ||||||
タイトル | 低線量放射線反復被ばくの発がんへの関与 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Relationship to Carcinogenesis of Repetitive Low-Dose Radiation Exposure | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 放射線 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低線量 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 反復被ばく | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 発がん | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | radiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | low-dose | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | repetitive irradiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | carcinogenesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
記事区分 | ||||||
値 | 総説 | |||||
著者 |
大津山, 彰
× 大津山, 彰× Ootsuyama, Akira |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 2008年HLEG(High Level Expert Group on European Low Dose Risk Research)は低線量影響研究の意義とその重要性を提唱し,発がんも含めて低線量放射線影響研究は国際的関心事となってきている[1,2].我々は長年動物実験を行っているが,放射線発がん実験は動物種の選択や,放射線の種類,量,照射方法など組合せが複雑で,解析もマクロからミクロ,分子生物学分野におよび,線量と効果の関係の目標を定めにくい領域である.我々の実験系では特異的自家発生がんが少ないマウスを選択し,目的の誘発がんとしてマウスで自家発生が希有な皮膚がんを選択した.また被ばくによる他臓器への影響を避け,かつ皮膚限局照射が可能なβ線を用いた.これにより照射部位の皮膚のみをがんの発生部位とし,他臓器の放射線影響を最小限にして長期反復被ばくを可能にし,放射線誘発腫瘍が生じる実験系を作った.照射は週3回反復照射で1回当りの線量を0.5~11.8 Gyまで段階的に線量を設定した.11.8~2.5 Gy線量域ではどの線量でも発がん時期と発がん率に変化はなかったが,この線量域から1.5~1 Gy線量域に1 回当りの線量を下げると発がん率に変化はみられず発がん時期の遅延が生じた.1回当りの線量0.5 Gyではマウスの生涯を通じ照射を続けてもがんは生じなかった.この結果はマウスでは,生涯低線量放射線被ばくを受け続けても生存中にがんが発生しない線量,つまりしきい値様線量が存在することを示している. We studied the carcinogenic effects caused by repetitive irradiation at a low dose, which has received attention in recent years, and examined the experimental methods used to evaluate radiation-induced carcinogenesis. For this experiment, we selected a mouse with as few autochthonous cancers as possible. Skin cancer was selected as the target for analysis, because it is a rare cancer in mice. Beta-rays were selected as the radiation source. The advantage of using beta-rays is weaker penetration power into tissues, thus protecting organs, such as the digestive and hematogenous organs. The benefit of our experimental method is that only skin cancer requires monitoring, and it is possible to perform long-term experiments. The back skin of mice was exposed repetitively to beta-rays three times a week until the occurrence of cancer or death, and the dose per exposure ranged from 0.5 to 11.8 Gy. With the high-dose range (2.5-11.8 Gy), the latency period and carcinogenic rate were almost the same in each experimental group. When the dose was reduced to 1-1.5 Gy, the latency period increased, but the carcinogenic rate remained. When the dose was further reduced to 0.5 Gy, skin cancer never happened, even though we continued irradiation until death of the last mouse in this group. The lifespan of 0.5 Gy group mice was the same as that of the controls. We showed that the 0.5 Gy dose did not cause cancer, even in mice exposed repetitively throughout their life span, and thus refer to 0.5 Gy as the threshold-like dose. |
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書誌情報 |
産業医科大学雑誌 en : Journal of UOEH 巻 38, 号 2, p. 175-183, 発行日 2016-06-01 |
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出版者 | ||||||
出版者 | 産業医科大学(産業医科大学学会) | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | ISSN 0387-821X(PRINT), ISSN 2187-2864(ONLINE) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.uoeh-u.ac.jp/kouza/journal/intro_e.html | |||||
関連名称 | Journal of UOEH | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.uoeh-u.ac.jp/kouza/journal/intro_j.html | |||||
関連名称 | 産業医科大学雑誌 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |