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5-アミノレブリン酸:悪性神経膠腫に対する術中蛍光診断におけるピットフォールと悪性神経膠腫治療への応用
https://uoeh-u.repo.nii.ac.jp/records/863
https://uoeh-u.repo.nii.ac.jp/records/863a1943593-8785-456c-9901-32be2ac5b9cc
名前 / ファイル | ライセンス | アクション |
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S00042103 (818.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-30 | |||||
タイトル | ||||||
タイトル | 5-アミノレブリン酸:悪性神経膠腫に対する術中蛍光診断におけるピットフォールと悪性神経膠腫治療への応用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-アミノレブリン酸 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | グリオーマ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ミトコンドリア標的薬 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 活性酸素種 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 放射線増感剤 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 5-aminolevulinic acid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | glioma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mitochondria-targeting drug | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | reactive oxygen species | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | radiosensitizer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
山本, 淳考
× 山本, 淳考× 北川, 雄大× 宮岡 , 亮× 鈴木, 恒平× 髙松 , 聖史郎× 齋藤, 健× 中野 , 良昭× Yamamoto , Junkoh× Kitagawa, Takehiro× Miyaoka , Ryo× Suzuki , Kohei× Takamatsu, Seishiro× Saito, Takeshi× Nakano, Yoshiteru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas. Although not a photosensitizer itself, 5-ALA is a prodrug that accumulates protoporphyrin IX (PpIX) in the mitochondria of glioma cells; PpIX acts as a photosensitizer. Fluorescence-guided resection for malignant gliomas has some pitfalls. Moreover, 5-ALA is not merely a fluorescence marker but has potential as a mitochondria-targeting drug for malignant glioma therapy. In this article, we review the literature related to 5-ALA, discuss the pitfalls of fluorescence-guided resection using 5-ALA for malignant gliomas, and describe the application of 5-ALA for malignant glioma therapy with personal opinions. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 5-アミノレブリン酸(5-ALA)は,悪性神経膠腫に対する術中蛍光診断における生体蛍光標識薬として広く利用されている.5-ALAそのものは光感受性物質ではなく,神経膠腫細胞のミトコンドリアにプロトポルフィリンIX(PpIX)を集積させるプロドラッグである.このPpIXが光感受性物質の性質を有する.5-ALAを用いた悪性神経膠腫に対する術中蛍光診断には,ピットフォールが存在する.また,5-ALAは,ただ単に蛍光診断薬ではなく,がん治療におけるミトコンドリア標的薬としての可能性を有する.本稿では,最新論文を基に5-ALAを用いた悪性神経膠腫に対する術中蛍光診断におけるピットフォールと5-ALAの悪性神経膠腫治療への応用について私見を加えて解説する. | |||||
書誌情報 |
産業医科大学雑誌 en : Journl of UOEH 巻 42, 号 1, p. 27-34, 発行日 2020-03-01 |
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出版者 | ||||||
出版者 | 産業医科大学(産業医科大学学会) | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | ISSN 0387-821X(PRINT), ISSN 2187-2864(ONLINE) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.uoeh-u.ac.jp/kouza/journal/intro_e.html | |||||
関連名称 | Journal of UOEH | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.uoeh-u.ac.jp/kouza/journal/intro_j.html | |||||
関連名称 | 産業医科大学雑誌 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |