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["炎症性乳癌とTrousseau症候群をきたし治療に難渋したLuminal A男性乳癌の1例"], "weko_shared_id": -1}
炎症性乳癌とTrousseau症候群をきたし治療に難渋したLuminal A男性乳癌の1例
https://uoeh-u.repo.nii.ac.jp/records/839
https://uoeh-u.repo.nii.ac.jp/records/839ccc7d3f7-0b29-4f57-816a-369d2ef9e5b8
名前 / ファイル | ライセンス | アクション |
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S00041211.pdf (10.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-31 | |||||
タイトル | ||||||
タイトル | 炎症性乳癌とTrousseau症候群をきたし治療に難渋したLuminal A男性乳癌の1例 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A Case Report of Luminal A Male Inflammatory Breast Cancer that Was Difficult to Treat Because of Trousseau Syndrome | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 男性乳癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 炎症性乳癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Trousseau 症候群 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 血栓傾向 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | male breast cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | inflammatory breast cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Trousseau syndrome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | thromboembolism | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
記事区分 | ||||||
値 | 症例報告 | |||||
著者 |
田嶋, 裕子
× 田嶋, 裕子× 草薙, 佳澄× 武田, 祐介× 吉松, 克真× 石田, 輝明× 篠原, 伸二× 平井, 文子× 今西, 直子× 市来, 嘉伸× 田中, 文啓× Tashima, Yuko× Kusanagi, Kasumi× Takeda, Yusuke× Yoshimatsu, Katsuma× Ishida, Teruaki× Shinohara, Shinji× Hirai, Ayako× Imanishi, Naoko× Ichiki, Yoshinobu× Tanaka, Fumihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 症例は67才男性.7年程前から左乳房腫瘤を自覚していたが放置.4ヶ月程前から左前胸壁全体に小腫瘤が多発したため最初に皮膚科を受診.皮膚生検で乳癌の皮膚転移と診断され当科への紹介となった.Estrogen receptor (ER)陽性,progesterone receptor (PgR)陽性,human epidermal growth factor recepter 2(HER2)陰性,Ki67は10-15%であり,サブタイプはluminal Aであった.2次性の炎症性乳癌をきたしており化学療法を先行.また下肢静脈に血栓の充満を認めたため抗凝固剤(エドキサバン)を開始.悪性腫瘍による血液凝固亢進状態(Trousseau 症候群)をきたしているためCVポートは造設せず,3週ごとのドセタキセル投与を3コース施行したが病状は増悪し,新たに右腸骨動脈の閉塞を認めたため,抗凝固剤をシロスタゾールとリバーロキサバンに変更したが,血栓改善なくさらに末梢循環不全のため左手第2指が壊死をきたし,その後第3指,4指の血流不全,第4指の壊死もきたした.FEC(5-FU,エピルビシン,シクロフォスファミド)療法を導入し4コース施行したところで病状はstable diseaseになったが血管確保が困難になり,化学療法をテガフール・ギメラシル・オテラシルカリウム(S-1)内服に変更し胸壁に対して強度変調放射線治療intensity modulated radiation therapy(IMRT)を施行した(IMRT中S-1 は中止).腫瘍の縮小効果は認めたが,次第に全身状態が悪化し治療開始後1年3ヶ月後に永眠された.今回血栓傾向をきたし治療に難渋した炎症性luminal A 男性乳癌の1例を経験したので報告する.進行癌患者の血栓傾向はしばしば報告されるが,男性乳癌患者は腫瘤を自覚してもすぐに来院せず,進行する傾向があるため,男性乳癌の啓蒙を行う必要がある. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This report describes the case of a 67-year-old male with inflammatory breast cancer. He had noticed a left breast mass about seven years previously, but he had ignored it. He then visited our hospital 4 months previously when multiple small masses occurred in the left front chest wall. The tumor was diagnosed as skin metastasis of breast cancer by skin biopsy and he was referred to our department. The tumor cells were positive for estrogen receptor and progesterone receptor, and negative for HER2/neu, and the Ki67 expression was 10-15%. The subtype of his breast cancer was luminal A type. It had secondary inflammatory breast cancer and preceded chemotherapy.Also, as the veins in the lower extremity were filled with thrombus, we gave him an anticoagulant (Edoxaban), but due to the malignant hyper coagulable state (Trousseau syndrome) a CV port could not be implanted. 3 courses of docetaxel every 3 weeks failed to control the disease. Since an obstruction of the right iliac artery was newly observed, the anticoagulant was changed to cilostazol and rivaroxaban, but left second finger and fourth finger necrosis occurred due to peripheral circulatory failure. The condition of the disease was stabilized by FEC (5-FU, epirubicin, cyclophosphamide) therapy, but it became difficult to secure the blood vessel. Without constructing a CV port because of the thrombus, chemotherapy was changed to S-1 oral administration, and strength to the chest wall Modulated radiotherapy intensity modulated radiation therapy (IMRT) was performed. Although the tumor was reduced, the condition of the whole body gradually weakened and the patient died a year and a half after the start of the treatment. This case of inflammatory luminal in male breast cancer that caused thrombus was difficult to treat. Thrombosis in advanced cancer patients is often pointed out, but since male breast cancer patients tend to takea long time to visit the hospital after becoming aware of the mass and arrive at an advanced state, it is necessary to notify the public of the existence of male breast cancer. | |||||
書誌情報 |
産業医科大学雑誌 en : Journal of UOEH 巻 41, 号 2, p. 211-216, 発行日 2019-06-01 |
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出版者 | ||||||
出版者 | 産業医科大学(産業医科大学学会) | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | ISSN 0387-821X(PRINT), ISSN 2187-2864(ONLINE) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/juoeh/41/2/_contents/-char/ja | |||||
関連名称 | Journal of UOEH | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.uoeh-u.ac.jp/kouza/journal/i_2019-2j.html | |||||
関連名称 | 産業医科大学雑誌 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |