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Small for Gestational Age児における成長ホルモン分泌不全の合併についての検討
https://uoeh-u.repo.nii.ac.jp/records/811
https://uoeh-u.repo.nii.ac.jp/records/8115cca5de9-a407-4569-90b1-b0610296a148
名前 / ファイル | ライセンス | アクション |
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S00040306.pdf (956.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-31 | |||||
タイトル | ||||||
タイトル | Small for Gestational Age児における成長ホルモン分泌不全の合併についての検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Evaluation of Clinical Features and Growth Hormone Deficiency in Short Children Born Small For Gestational Age | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 低身長 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 成長ホルモン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インスリン様成長因子 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | short stature | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | growth hormone | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | insulin-like growth factors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
記事区分 | ||||||
値 | 原著 | |||||
著者 |
池上, 朋未
× 池上, 朋未× 荒木, 俊介× 桑村, 真美× 多久, 葵× 斎藤, 玲子× 後藤, 元秀× 久保, 和泰× 川越, 倫子× 山本, 幸代× 河田, 泰定× 楠原, 浩一× Ikegami, Tomomi× Araki, Shunsuke× Kuwamura, Mami× Taku, Aoi× Saito, Reiko× Goto, Motohide× Kubo, Kazuyasu× Kawagoe, Rinko× Yamamoto, Yukiyo× Kawada, Yasusada× Kusuhara, Koichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Small for gestational age(SGA)性低身長症に対する成長ホルモン(GH)治療は投与量や医療費の公的補助が成長ホルモン分泌不全症(GHD)と異なることから,治療開始前にGH分泌能を評価することが重要である.本研究は低身長のSGA児におけるGHD合併の頻度とGHDを検出する有用な指標を明らかにすることを目的とした.産業医科大学病院および九州労災病院にてGH治療を開始したSGA児について診療録を用いて後方視的に検討した.6歳以下でGH治療を開始した22例のSGA児のうち9例(41%)がGHDを合併していた.GHD合併の有無による出生時の在胎期間,身長,体重,GH療法開始時の身長およびインスリン様成長因子(insulin-like growth factors: IGF)-1値に有意差は無かった.しかし,身長の標準偏差(SD)が-3.2を下回ると有意にGHDの合併頻度が上昇し,感度55.6%,特異度84.6%,オッズ比11.6(95%信頼区間 1.52 - 89.1,P = 0.013)となり,身長SDはGHDを検出する有用な指標であった.本研究では低身長のSGA児の40%がGHDを合併していた.特に-3SDを下回る症例では,GHDの合併が多く,適切な診断に基づいたGH 治療を行うためには,積極的にGH分泌能の評価を行う必要がある. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Growth hormone (GH) therapy for short children born small for gestational age (SGA) has been approved in Japan. It is important to evaluate GH secretion ability before the initiation of GH therapy because there are some differences in dose and medical expenses between short children born SGA and GH deficiency (GHD). This study was designed to elucidate the incidence of GHD and to find a useful marker for detecting it in short SGA children.We retrospectively reviewed medical records to analyze the clinical features of short children born SGA and with GHD who had started GH therapy before the age of 6 in the University Hospital of Occupational and Environmental Health and Kyushu Rousai Hospital. Nine of 22 SGA subjects (41%) had GHD. There were no significant differences between two groups of short SGA children (GHD, non-GHD) in the median of height and serum insulin-like growth factors (IGF)-1 levels at birth or at the start of GH therapy. The probability of GHD was higher if the height standard deviation scores (SD) of the SGA children were lower than -3.2 (odds ratio, 11.6; 95% confidence interval, 1.52 - 89.1, P = 0.013). This study showed that there is an approximately 40% incidence of GHD in short SGA children needing GH treatment. We should do GH stimulation tests for short SGA children whose height SD is lower than -3 to determine the appropriate GH therapy. | |||||
書誌情報 |
産業医科大学雑誌 en : Journal of UOEH 巻 40, 号 3, p. 253-257, 発行日 2018-09-01 |
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出版者 | ||||||
出版者 | 産業医科大学(産業医科大学学会) | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | ISSN 0387-821X(PRINT), ISSN 2187-2864(ONLINE) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/juoeh/40/3/_contents/-char/ja | |||||
関連名称 | Journal of UOEH | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.uoeh-u.ac.jp/kouza/journal/i_2018-3j.html | |||||
関連名称 | 産業医科大学雑誌 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |