@article{oai:uoeh-u.repo.nii.ac.jp:00000842,
 author = {笠井, 謙多郎 and 田中, 敏子 and 佐藤, 寛晃 and Kasai, Kentaro and Tanaka, Toshiko and Satou, Hiroaki},
 issue = {2},
 journal = {産業医科大学雑誌, Journal of UOEH},
 month = {Jun},
 note = {特殊環境下で約5年が経過した検体から薬物を検出することができた事例を経験した．一部が白色から黒褐色に変色して硬く，いわゆる“屍蝋化”の状態であった大腿筋および骨髄を試料として，QuEChERS法による抽出の後，高速液体クロマトグラフィー質量分析装置（LC-MS/MS）により薬毒物スクリーニング検査を行ったところスルピリドおよびエスタゾラムを検出できた．大腿筋でのスルピリドとエスタゾラムの濃度を測定するとそれぞれ10.6 ng/gおよび39.9 ng/gであった．本結果は死因診断のみならず，両薬物の同時服薬履歴から身元特定にもつながった．薬毒物分析技術の進歩により，以前であれば薬毒物を検出することが困難であった陳旧な検体や特殊環境下の検体からも薬毒物を検出できるようになりつつあるが，本事例のように経過時間が5年とかなり長く屍蝋化した検体からの薬毒物検出の報告はない．薬毒物分析技術の進歩に伴いその結果は死因の診断のみならず個人識別の分野への応用が可能である．, We had a forensic autopsy case in which drugs were detected in a cadaver that had been stored in a cold and wet condition for 5 years. The skin of the cadaver was hard, and the color was partly whitish or dark brown.Though the cadaver had transformed into adipocere in the wet and cold condition, QuEChERS extraction and LCMS/MS revealed the presence of sulpiride and estazolam in the femoral muscle and bone marrow. The concentrations of sulpiride and estazolam in the femoral muscle were 10.6 ng/g and 39.9 ng/g, respectively. The result of a drug screening test led not only to the cause of death but also to the personal identification of the cadaver. The individual had a history of drug taking, which had been stored in his medical records at the hospital for a long time.The fact of taking sulpiride and estazolam at the same time was characteristic, and it was useful in identifying the cadaver in this case. The progress in analytical technology has made possible the detection of particle drugs from old or adipoceratous cadavers, but there have been no reports of particle drugs being detected in a cadaver that had been dead for 5 years and had transformed to adipocere, as in our present case. The analytical results by LC-MS/MS were certainly important for the diagnosis of the cause of death, and, moreover, they were useful for the purpose of personal identification.},
 pages = {231--237},
 title = {全身屍蝋化した死体から薬物を検出した法医剖検事例},
 volume = {41},
 year = {2019}
}