@article{oai:uoeh-u.repo.nii.ac.jp:00000741,
 author = {森 , 博子 and 岡田 , 洋右 and 川口 , 真悠子 and 田中, 良哉 and Mori, Hiroko and Okada, Yosuke and Kawaguchi, Mayuko and Tanaka, Yoshiya},
 issue = {2},
 journal = {産業医科大学雑誌, Journal of UOEH},
 month = {Jun},
 note = {Dapagliflozin, a selective inhibitor of sodium glucose co-transporter 2 (SGLT2), is a novel glucose-lowering agent that has pleiotropic actions on blood pressure and lipids. Its glucose-lowering effect is not mediated by insulin. We report a type 2 diabetic patient whose blood pressure pattern improved from non-dipper to dipper after treatment with dapagliflozin. The 60-year-old man was treated with 5 mg/day dapagliflozin, and the effect of treatment on his blood pressure (BP) was evaluated by ambulatory blood pressure monitoring (ABPM) before and at 8 and 14 days after the start of treatment. The 24-h systolic blood pressure/diastolic blood pressure decreased from 131/87 to 127/83 mmHg at day 14, with a particular decrease in nocturnal blood pressure from 123/84 to 116/75 mmHg (nocturnal blood pressure dip increased from 9.6% to 12.8%), changing from a non-dipper to a dipper blood pressure pattern. Dapagliflozin might potentially improve not only the average blood pressure, but also nighttime blood pressure from non-dipper to dipper in type 2 diabetic patients. 
ダパグリフロジンは，SGLT2阻害薬（selective inhibitor of sodium glucose co-transporter 2）のひとつであり，インスリンを介さずに血糖値を改善する作用機序を有する新規2型糖尿病治療薬である．その効果は血糖改善のみならず，血圧，脂質などへの多面的な作用がある．今回，2型糖尿病患者にダパグリフロジンを投与し，血圧がnon-dipperからdipperに改善した症例を経験したので報告する．60歳男性の2型糖尿病患者に対し，ダパグリフロジン5 mg/日を投与し，血圧への影響を評価した．血圧は，投与前，投与後8日目，14日目にABPM （24 hour ambulatory blood pressure monitoring） を測定した．24時間血圧は収縮期血圧：systolic blood pressure （SBP）/拡張期血圧：diastolic blood pressure （DBP） 131/87 mmHgから127/83 mmHgに低下した．中でも，夜間血圧は123/84 mmHgから116/75 mmHgに低下した．その結果，夜間血圧下降度は，9.6 %から12.8 %と上昇し，血圧はnon-dipperからdipperとなった．ダパグリフロジンは平均血圧のみならず，夜間血圧を降下させnon-dipperからdipperへ改善する可能性がある．},
 pages = {149--153},
 title = {ダパグリフロジンで血圧がnon- dipper型からdipper型に変わった2型糖尿病の1例},
 volume = {38},
 year = {2016},
 yomi = {モリ, ヒロコ and オカダ, ヨウスケ and カワグチ, マユコ and タナカ, ヨシヤ}
}